I recently animated a Mixamo character in Blender. I had some difficulties with hands - Mixamo T-pose has palms down, I needed palms up (for juggling). Rotating hands/forearms 180 degrees with animations seemed to cause big issues. Eventually I just modified the character T-pose to have palms up.
Wouldn't the most useful T-pose be palms forward? Then you should be able to rotate 90 degrees up or down. Does this issue pop up often? Is there a better solution/workaround than mine?
Final result is at: https://cgcookie.com/projects/robot-juggler
(Used IK on hands/arms)