What addon can we use to make the painting process more user friendly?
Can you have to activate a lot of options in each window.
I don't know of any specific one. You can always browse the Blender Market
Or take a look at Jonathan Lampel's ultimate guide for the best addons.
https://cgcookie.com/posts/the-ultimate-2022-guide-to-the-best-blender-add-ons
What about substance painter to paint textures?
Jonathan recommended it. It seems more intuitive and easy to use.
He made a tutorial as to how to work in parallele with Blender and Substance. It's intuitive.