Little Grandma, as usual box modeling done in blender, detail sculpting and body/face/hair polypainted in zbrush, clothes and accessories textured with Photoshop.
This image was render with cycles, post processed in Photoshop.
Rigged in Blender, available as a Second Life avatar.
See more here : http://wheresmypencil.tumblr.com/post/97903861984/little-grandma-as-usual-box-modeling-done-in