I got freaked out once when I thought they had change those hotkeys. I downloaded a new Blender, tried to G to grab, S to scale, R to rotate, and they weren't working, and I'm like Oh my god! they changed all the hotkeys! This is sacrilegious. Turned out my Keyboard batteries had just died right at that moment. I'm using 4.1 and everything works as always. Try re-downloading Blender 4.1 and updating drivers on your PC, see if any of that helps.
I'd try file->defaults->load factory settings. See if that fixes it. If not then redownload blender. Uninstall and reinstall blender.
The most likely places in the Keymap Preferences, that change those main shortcuts are here:
If this happens again, or if someone else sees this, there is no need to re-install all Addons and so.
"Load Factory Settings" is great to see if your hardware might be a problem, or if problems arise due to some Setting in your Preferences, or maybe a 3rd party Addon, because it isn't permanent (it doesn't change your Startup File).